Bronchiectasis neutrophils show reduced CD11b and lower granule protein release than controls
James D Chalmers said on X that his team's study found lower CD11b and granule protein release in bronchiectasis neutrophils compared with controls, contrary to some earlier reports.
“Some previous studies suggested hyperactivation of neutrophils in bronchiectasis in the peripheral blood but we didn't find that.”— James D Chalmers
Neutrophils from people with bronchiectasis showed reduced CD11b and lower release of granule proteins compared with controls, according to findings described by James D Chalmers on X.
Chalmers, Rhodes Chair of Experimental Therapeutics at the University of Oxford and Chief Editor of the European Respiratory Journal, wrote that the team reports these results in their study. He described them as "provocative". He said he was posting in a personal capacity.
Chalmers noted that some previous studies had suggested hyperactivation of neutrophils in the peripheral blood in bronchiectasis. He said his team did not find this in their own work.
The post did not give further details of the study, such as its design, sample size or the journal in which it appears. It includes a link, but the linked content was not part of the source material.
Original source
“Some previous studies suggested hyperactivation of neutrophils in bronchiectasis in the peripheral blood but we didn't find that.”
— James D Chalmers View the post on X
